An experimental evaluation of the optimal method of use of streptokinase in venous thrombosis

Experiments have been carried out in dogs to determine the optimal method of use of streptokinase in venous thrombosis. The experiments show that:– High-dose regional infusion is the most efficient system of producing thrombolysis.Occlusive thrombi are readily removed by this system.Low-dose regional infusions and high-dose systemic infusions are much less efficient but, in general, regional delivery is preferable when possible. As a result of these experimental conclusions a number of patients have been successfully treated with high-dose regional infusions of streptokinase (Mavor, Bennett, Galloway, and Karmody, 1969; Mavor, Galloway, and Karmody, 1970).