Population
Isolated left atria of guinea pigs
Comparison
Carbachol administration and washout, under the… vs Baseline/control levels before drug…
Design
Preclinical
Authors
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Hypothesis-generating for calcium-mediated cholinergic effects in atria; human studies needed before any clinical consideration.
The dissociation between electrical and mechanical responses to carbachol in guinea pig atria indicates that mechanical fading and hypercontractility are driven by cellular calcium distribution changes rather than altered receptor sensitivity.
Gertjegerdes et al. (1979) studied this question.
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