Why the study?
Is the rs74577862 variant in the ADIPOQ gene associated with an increased risk of atherosclerosis in a Chinese population?
Is the rs74577862 variant in the ADIPOQ gene associated with an increased risk of atherosclerosis in a Chinese population?
The rs74577862 variant in the ADIPOQ gene is associated with an increased risk of carotid and coronary atherosclerosis in a Chinese population, supported by functional evidence of decreased gene expression.
Hypothesis-generating for ADIPOQ variants; should not yet change clinical practice or risk stratification.
// Xinzhong Chen 1 , Yanhong Yuan 1 , Yufeng Gao 2 , Qin Wang 1 , Fei Xie 1 , Dongsheng Xia 3 , Yutao Wei 1 and Ting Xie 4 1 Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China 2 Department of Neurology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China 3 Department of Cardiovascular Surgery, Henan Provincial People’s Hospital, Zhengzhou, 450003, China 4 Department of Cardiac Surgery, Hainan Provincial People’s Hospital, Hainan 570311, China Correspondence to: Xinzhong Chen, email: chen_xinzhong@sina.cn Keywords: ADIPOQ, adiponectin, atherosclerosis, polymorphism Received: June 13, 2017 Accepted: August 04, 2017 Published: September 23, 2017 ABSTRACT The burden of atherosclerosis is heritable and associated with elevated risk of developing CVDs. Here, we evaluated genetic variants of adiponectin (ADIPOQ) gene, which has important role in anti- atherosclerosis, with risk of atherosclerosis among a large Chinese population. Our results show that rs74577862 was significantly associated with risk of atherosclerosis (OR=2.08; 95%CI=1.48-2.91; P=2.2×10 -5 ). When stratified by atherosclerosis site, rs74577862 was associated with increased risk of both carotid atherosclerosis (OR=2.03; 95%CI=1.35-3.06; P=6.3×10-4) and coronary atherosclerosis (OR=2.11; 95%CI=1.44-3.09; P=1.1×10-4). In addition, we also carried out site-directed mutagenesis and dual-luciferase reporter assay to confirm the positive finding, which presents a significant decrease in luciferase expression for the reconstructed plasmid with rs74577862 A allele in comparison to the one with G allele (P
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Chen et al. (2017) studied this question.
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