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The ontogeny of the immunoglobulin G (IgG) immune response in experimental syphilis was determined by use of an antitreponemal microassay (SPA-TP) in which radioiodinated staphylococcal protein A (SPA) was used. Results were compared with those obtained in the same rabbits by use of the Venereal Disease Research Laboratory (VDRL), fluorescent treponemal antibody-absorption (FTA-Abs), and Treponema pallidium immobilization (TPI) tests. Of the four serologic tests, only the SPA-TP and TPI assays gave results that correlated significantly over the entire 17-month period of infection. Preliminary evidence indicated that the antibody detected by the SPA-TP microassay may correlate quantitatively with the state of host immunity as determined by in vivo challenge; if this finding is confirmed, the SPA-TP microassay could be applied for assessment of the immune status in syphilis.
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PEPOSE et al. (1980) studied this question.
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