Why the study?
Trypanosoma cruzi presents great variability in morphology, virulence, pathogenicity, host immune evasion, and antigenic constitution associated with different clinical manifestations.
The isolated T. cruzi strains belong to Group TcI, which is associated with cardiac manifestations, highlighting a potential future public health issue as the vector adapts to home environments.
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Strain variability in T. cruzi may affect Chagas outcomes; leaves open clinical translation and needs in vivo validation.
BACKGROUND: Trypanosoma cruzi presents great variability in morphology, virulence, pathogenicity, avoidance of the host immune system, and antigenic constitution, associated with different clinical manifestations of the disease. METHODS: Two strains of T. cruzi were cultivated in liver infusion tryptose to determine growth kinetics, morphometry and molecular characterization using restriction fragment length polymorphism polymerase chain reaction. RESULTS: The biological parameters showed sharp growth by the 7th day. Morphologically, both strains showed short and thin forms and were classified as Group I. CONCLUSION: Group TcI presents cardiac manifestations and T. sherlocki is adapting to the home environment, requiring attention to future problems.
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Kunii et al. (2022) studied this question.
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