Why the study?
LV spherical remodeling commonly develops in dilated cardiomyopathy and is associated with poor prognosis and reduced cardiac performance, but its mechanism remains unclear.
Modification of mitral valve complex tissue elongation could be a potential therapeutic target for preventing or treating left ventricular spherical remodeling in dilated cardiomyopathy.
Associates MVC elongation mismatch with LV sphericity in DCM; hypothesis-generating and leaves open therapeutic relevance pending prospective data.
Left ventricular (LV) spherical remodeling is associated with poor prognosis and less-effective cardiac performance, which commonly develops in dilated cardiomyopathy. However, its mechanism remains unclear. We hypothesized and subsequently clarified that less mitral valve complex (MVC) tissue longitudinal elongation relative to whole LV myocardial tissue longitudinal elongation is related to disproportionately less LV base longitudinal versus transverse myocardial tissue elongation, constituting spherical remodeling. This study suggests modification of MVC tissue elongation could be potential therapeutic targets.
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Nagata et al. (2020) studied this question.
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