Describes a novel synthetic method for generating uridylylated picornavirus VPg proteins, which are essential for viral replication.
Small proteins called viral protein genome-linked (VPg), attached to the 5'-end of the viral RNA genome are found as common structure in the large family of picornaviruses. The replication of these viruses is primed by this VPg protein linked to a single uridylyl residue. We report a general procedure to obtain such nucleoproteins employing a pre-uridylylated tyrosine building block in an on-line solid phase-based approach.
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Noort et al. (2013) studied this question.
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