July 1, 1969Acta Physiologica Scandinavica

The Relative Role of Recapture and of de novo Synthesis for the Maintenance of Neurotransmitter Homeostasis in Noradrenergic Nerves

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Population

Isolated, perfused cat spleen

Design

Preclinical

Authors

PHPer HedqvistBoston University LSL. StjärneKarolinska Institutet

Discussion

Member takes

Implication

Reuptake maintains noradrenaline during sympathetic activation in this model; leaves open translation to human cardiovascular regulation.

Structured PICO

Population

Isolated, perfused cat spleen

Intervention

Electrical nerve stimulation with nialamide pretreatment and addition of phenoxybenzamine or cocaine + Hydergin to perfusion fluid

Outcome

Rate of de novo synthesis of noradrenaline compared to discharge/overflow of noradrenalinesurrogate

The major mechanism for maintaining constant noradrenaline levels during increased nerve activity is almost quantitative reuptake rather than de novo synthesis.

Cite This Study

Hedqvist et al. (1969) studied this question.

synapsesocial.com/papers/6a9236a693d3c78593383eb6 https://doi.org/10.1111/j.1748-1716.1969.tb04470.x

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The Relative Role of Recapture and of de novo Synthesis for the Maintenance of Neurotransmitter Homeostasis in Noradrenergic Nerves

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Relative Role of Recapture and of de novo Synthesis for the Maintenance of Neurotransmitter Homeostasis in Noradrenergic Nerves

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider