Demonstration of Eosinophil Chemotactic Factor in the Blister Fluid of Patient With Incontinentia Pigmenti

A case of incontinentia pigmenti associated with tissue and peripheral blood eosinophilia was reported. Eosinophil chemotactic factor (ECF) with low molecular weight was detected in the blister fluid at 17 days after birth by an in vitro chemotactic assay. ECF showed two different molecular weights; one was approximately 1355 daltons and the other much smaller. A similar factor was also detected in the content of a suction blister in clinically uninvolved skin at 2 months after birth. Investigations of ECF generation appears to be important in understanding of this disease.