Why the study?
The study evaluated the circadian efficacy of a telmisartan 40 mg/S-amlodipine 2.5 mg fixed-dose combination compared to telmisartan 80 mg in patients with essential hypertension not responding to 2-4 weeks of telmisartan 40 mg.
Does a fixed-dose combination of telmisartan 40 mg/S-amlodipine 2.5 mg improve circadian blood pressure compared to telmisartan 80 mg in patients with essential hypertension not responding to telmisartan 40 mg?
Population
217 Korean patients with essential hypertension unresponsive to 2-4 weeks of telmisartan 40 mg
Comparison
Telmisartan 40 mg/S-amlodipine 2.5 mg fixed-dose combination vs telmisartan 80 mg
Design
Randomized trial
Follow-up
8 weeks
Authors
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Low-dose combination outperforms telmisartan dose escalation for 24-h BP control in non-responders; leaves open confirmation in larger diverse trials.
Does a fixed-dose combination of telmisartan 40 mg/S-amlodipine 2.5 mg improve circadian blood pressure compared to telmisartan 80 mg in patients with essential hypertension not responding to telmisartan 40 mg?
A fixed-dose combination of telmisartan and S-amlodipine is more effective than doubling the dose of telmisartan monotherapy for lowering 24-hour ambulatory blood pressure in patients with uncontrolled essential hypertension.
Kim et al. (2022) studied this question.