The microbial growth of the probiotic strain Lactobacillus delbrueckii ssp. bulgaricus B1, cultivated in a complex nutrient medium (MRS-broth), was studied in the present work. The complex nutrient medium provides not only the carbon source necessary for the growth of biomass, but also all the additional sources of nitrogen, phosphorus and other components that the biomass needs for its growth. The use of non-structural mathematical dependences determines the optimal conditions (substrate concentration) for the accumulation of biomass or lactic acid, depending on the needs of the specific production.
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Kostov et al. (2022) studied this question.
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