Various 1-arylcyclohexylamines were synthesized for evaluation as central nervous system depressants. The compounds were prepared by several procedures. 1-(1-Phenylcyclohexyl)piperidine, the first compound of this type synthesized, was prepared from 1-piperidinocyclohexanecarbonitrile by replacement of the cyano group by phenyl using phenylmagnesium bromide. These compounds were tested for cataleptoid activity and antitonic extensor properties.
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Maddox et al. (1965) studied this question.