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Suggests that subdividing heart failure into strictly systolic and diastolic phenotypes may be obsolete based on systems biology approaches.
S hould chronic heart failure (HF) be subdivided into 2 distinct phenotypes?Current knowledge supports the view that the complexity of HF cannot be captured by answering this question with a yes or a no.Recent developments in the biosciences, particularly systems biology approaches and studies of phenotypic disease networks, have indicated that such questions are becoming obsolete, and perhaps even irrelevant.
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Keulenaer et al. (2011) studied this question.
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