July 1, 1993AJP Endocrinology and Metabolism

NPY is not a primary mediator of the acute thyroid blood flow response to sympathetic nerve stimulation

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Population

Anesthetized male rats (250-300 g)

Comparison

Norepinephrine and Neuropeptide Y alone or… vs Saline-infused rats; sham stimulation

Design

Preclinical

Authors

MDM. Dey MMM Michalkiewicz LHL. HuffmanJohns Hopkins University

Discussion

Member takes

Implication

Alpha-adrenergic receptors mediate acute sympathetic reduction in thyroid vascular conductance in rats; leaves open translation to human thyroid physiology.

Structured PICO

Population

Anesthetized male rats (250-300 g)

Intervention

Norepinephrine (15 nmol iv bolus) and Neuropeptide Y (12 or 1.7 nmol/kg iv infusion for 4 min) alone or together, with or without phentolamine (10 mg/kg iv bolus); cervical sympathetic trunk stimulation (30 Hz, 10 V, 0.5 ms, 2 min) with or without phentolamine

Comparator

Saline-infused rats; sham stimulation

Outcome

Thyroid vascular conductance (TVC) measured by laser-Doppler blood flowmetrysurrogate

NPY is not the primary mediator of the acute reduction in thyroid blood flow following sympathetic nerve stimulation, which is instead mediated by alpha-adrenergic receptors.

Cite This Study

Dey et al. (1993) studied this question.

synapsesocial.com/papers/6a924d0a397d2e5be3b88939 https://doi.org/10.1152/ajpendo.1993.265.1.e24

View Full Paper

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Implication

Alpha-adrenergic receptors mediate acute sympathetic reduction in thyroid vascular conductance in rats; leaves open translation to human thyroid physiology.

NPY is not a primary mediator of the acute thyroid blood flow response to sympathetic nerve stimulation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

NPY is not a primary mediator of the acute thyroid blood flow response to sympathetic nerve stimulation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider