Why the study?
Does standard ACEI plus candesartan reduce proteinuria and blood pressure more than a 50% increase in ACEI dose in patients with chronic renal disease?
Population
Patients with chronic renal disease
Comparison
Standard dose of angiotensin-converting enzyme… vs 50% increase in the dose of…
Design
RCT, Randomized intervention periods mentioned, followed by a sequential phase…
Authors
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May warrant dual RAS blockade over ACEI uptitration in proteinuric CKD; extends evidence for combination therapy.
Does standard ACEI plus candesartan reduce proteinuria and blood pressure more than a 50% increase in ACEI dose in patients with chronic renal disease?
Dual blockade with a standard ACEI plus candesartan is more effective at reducing proteinuria and systolic blood pressure than increasing the ACEI dose by 50% in patients with chronic renal disease.
Kincaid‐Smith et al. (2004) studied this question.
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