Elevated Levels of α-Globulins in Sera From Germfree Rats With 3-Methylcholanthrene-Induced Tumors 2 3

Mean levels of α-globulins were high in sera from germfree Sprague-Dawley rats with 3-methylcholanthrene-induced tumors, compared to the α-globulin levels in sera from control germfree rats of the same strain. The second fraction in the α-globulin zone of sera from tumor-bearing rats was not detected in the control counterparts. Mean total α-globulin values dropped to normal levels at 3 weeks after extirpation of fibrosarcomas. However, while the second α-globulin fraction values did not disappear completely, they fell to much lower levels, comparatively. The relation of these findings to oncogenesis is discussed.