Reversal of Long-Standing Renal Insufficiency by Captopril in a Patient with Relapsing Hemolytic Uremic Syndrome Due to an Oral Contraceptive

Brief Reports1 March 1981Reversal of Long-Standing Renal Insufficiency by Captopril in a Patient with Relapsing Hemolytic Uremic Syndrome Due to an Oral ContraceptiveSTEVEN J. HOORNTJE, M.D., ERIK J. L. PRINS, M.D., ANDRIES J. SMIT, M.D., AB J. M. DONKER, M.D.STEVEN J. HOORNTJE, M.D.Search for more papers by this author, ERIK J. L. PRINS, M.D.Search for more papers by this author, ANDRIES J. SMIT, M.D.Search for more papers by this author, AB J. M. DONKER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-3-355 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptVarious diseases, including the hemolytic uremic syndrome, produce renal functional changes by compromising renal circulation. Narrowing of the arteriolar lumen can lead to hypertension in a manner analogous to the Goldblatt mechanism (1). This condition may be managed successfully by blockade of the renin-angiotensin system (2).We report reversal of hypertension and renal failure by captopril in a patient with the hemolytic uremic syndrome. A second attack occurred during captopril treatment shortly after the patient accidentally reinstituted use of the same oral contraceptive she had used before the first attack.A 17-year old woman was admitted in 1977 because of...References1. DAVSON J, BALL J, and PLATT R. The kidney in periarteritis nodosa. Q J Med. 1948;17:175-202. MedlineGoogle Scholar2. LOPEZ-OVEJERO J, SAAL S, D'ANGELO W, CHEIGH T, STENZEL K, and LARAGH J. Reversal of vascular and renal crises of scleroderma by oral angiotensin-converting-enzyme blockade. N Engl J Med. 1979;300:1417-9. CrossrefMedlineGoogle Scholar3. DARRACOTT VAUGHAN E, CAREY R, DYERS C, and PEACH M. Hemodialysis-resistant hypertension: control with an orally active inhibitor of angiotensin-converting enzyme. J Clin Endocrinol Metab. 1979;48:869-71. CrossrefMedlineGoogle Scholar4. BRUNNER H, GAVRAS H, and WAEBER B. Oral angiotensin-converting enzyme inhibitor in long-term treatment of hypertensive patients. Ann Intern Med. 1979;90:19-23. LinkGoogle Scholar5. MACCREDIE D and POWELL H. Use of a converting-enzyme inhibitor in severe hypertension of end-stage renal failure. Austr N Zeal J Med. 1980;10:123. CrossrefGoogle Scholar6. SWARTZ S, WILLIAMS G, HOLLENBERG N, MOORE T, and DLUHY R. Converting-enzyme inhibition in essential hypertension: the hypotensive response does not reflect only reduced angiotensin II formation. Hypertension. 1979;1:106-11. CrossrefMedlineGoogle Scholar7. SWARTZ S, WILLIAMS G, HOLLENBERG N, LEVINE L, DLUHY R, and MOORE T. Captopril-induced changes in prostaglandin production. Relationship to vascular responses in normal man. J Clin Invest. 1980;65:1257-64. CrossrefMedlineGoogle Scholar8. GAVRAS H, BROWN J, LEVER A, MACADAM R, and ROBERTSON J. Acute renal failure, tubular necrosis and myocardial infarction induced in the rabbit by intravenous angiotensin II. Lancet. 1971;2:19-22. CrossrefMedlineGoogle Scholar9. BROWN C, CLARKSON A, ROBSON J, CAMERON J, THOMSON D, and OGG C. Hemolytic uremic syndrome in women taking oral contraceptives. Lancet. 1973;1:1479-81. CrossrefMedlineGoogle Scholar10. DONKER A, VAN D, HEM G, SLUITER W, and BEEKHUIS H. A radio-isotope method for simultaneous determination of the glomerular filtration rate and the effective renal plasma flow. Ned J Med. 1977;20:97-103. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: STEVEN J. HOORNTJE, M.D.; ERIK J. L. PRINS, M.D.; ANDRIES J. SMIT, M.D.; AB J. M. DONKER, M.D.Affiliations: State University Hospital Groningen Groningen, the Netherlands. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGuidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemiasHemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome: a review of diagnosis and managementThrombotic MicroangiopathyRecovery from “End-Stage” Renal DiseaseRecovery of Renal Function in Patients on Maintenance DialysisHemolytic-uremic syndromePostpartum haemolytic uraemic syndrome precipitated by antibiotics. Case reportAcute Renal Failure in PregnancyHypertension in Renal Parenchymal DiseaseVesicoureteral Reflux and Reflux NephropathySex hormones and related compounds, including oral contraceptives 1 March 1981Volume 94, Issue 3Page: 355-357KeywordsHemolytic-uremic syndromeHypertensionOral contraceptive therapyOral diseasesRenal circulationRenal diseasesRenal failure ePublished: 1 December 2008 Issue Published: 1 March 1981 PDF downloadLoading ...