January 1, 2001Journal of Hypertension

Linkage of hypertension to chromosome 2q14-q23 in Chinese families

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Structured PICO

Population

Chinese siblings with hypertension ascertained through outpatient clinics. Stage 1: 283 affected sib-pairs from 79 nuclear families; Stage 2: 637 affected sib-pairs from 161 families; Stage 3: 777 affected sib-pairs from 106 families.

Intervention

Genome-wide scan and fine-scale mapping using microsatellite markers

Outcome

Evidence for linkage and association to hypertension susceptibility genes (assessed via LOD scores and NPL Z-scores)surrogate

The study identifies a suggestive region on chromosome 2q14-q23 linked to hypertension susceptibility in Chinese families, overlapping with blood pressure quantitative trait loci found in rat models.

Discussion

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Implication

Hypothesis-generating for a 2q14-q23 hypertension locus; replication and fine-mapping needed before clinical relevance.

Cite This Study

Zhu et al. (2001) studied this question.

synapsesocial.com/papers/6a925ebf7804045360963b46 https://doi.org/10.1097/00004872-200101000-00008

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Linkage of hypertension to chromosome 2q14-q23 in Chinese families

Structured PICO

Discussion

Implication

Cite This Study

Topics

Linkage of hypertension to chromosome 2q14-q23 in Chinese families

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider