Why the study?
Does the interaction between atrial natriuretic factor and ouabain alter vascular reactivity to noradrenaline in anaesthetized dogs?
Population
Pentobarbital anaesthetized dogs with denervated and flow-controlled hindlimb preparations
Comparison
Intra-arterial infusion of rat atrial… vs Baseline/control levels or alternate infusion…
Design
Preclinical
Follow-up
up to 60 minutes or longer
Authors
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May indicate ANF-ouabain antagonism on vascular reactivity in dogs; hypothesis-generating and should not yet change practice.
Does the interaction between atrial natriuretic factor and ouabain alter vascular reactivity to noradrenaline in anaesthetized dogs?
The study demonstrates a physiological antagonism between ANF and ouabain on vascular smooth muscle reactivity to noradrenaline.
Chintala et al. (1988) studied this question.
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