Poliomyelitis virus can be lyophilized with retained infectivity and exhibits partial heat resistance in its dry state, suggesting potential epidemiological implications for its survival in nature.
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May inform lab virus preservation methods; leaves open any role in natural polio epidemiology.
Data are presented showing that the MEF1 (Type 2) baby mouse adapted strain of poliomyelitis virus can be lyophilized with little loss of infectious activity. The same appears to be true of the Leon (Type 3) mouse adapted strain. 2. Heating the dry MEF1 virus indicates that, although part of the viral population appears to be relatively heat labile, a measurable proportion of the virus particles is quite resistant to heat. 3. The epidemiological implications of the possible presence of dry poliomyelitis virus in nature are discussed.
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Kraft et al. (1954) studied this question.
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