Why the study?
While individual case reports describe QTc prolongation and cardiac arrhythmias from trazodone overdose, the clinical effects and outcomes on a large-scale basis remain less well known.
Single-substance trazodone exposures are generally of low severity with infrequent cardiac-related clinical effects, though a dose-response relationship exists for the level of care required.
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Most trazodone exposures are low-severity; leaves open refined dose thresholds for cardiac monitoring.
Husak et al. (2022) studied this question.
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