June 11, 2004Journal of VirologyOpen Access

RNA Interference Targeting VP1 Inhibits Foot-and-Mouth Disease Virus Replication in BHK-21 Cells and Suckling Mice

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Population

BHK-21 cells and suckling mice

Design

Preclinical

Follow-up

up to 48 h postinfection (in vitro)

Authors

WCWeizao ChenNational Institutes of Health WYWeiyao YanInstitute of Plant Protection QDQingyun DuGansu Agricultural University

Discussion

Member takes

Implication

siRNA targeting VP1 shows in vivo antiviral activity in mice; leaves open translation to livestock or therapeutic use.

Structured PICO

Population

BHK-21 cells and suckling mice

Intervention

Small interfering RNA (siRNA) targeting VP1 of foot-and-mouth disease virus (FMDV) via siRNA-expressing plasmids

Outcome

FMDV replication and susceptibility to FMDV infectionsurrogate

siRNA targeting the VP1 protein of FMDV effectively inhibits viral replication in vitro and in vivo, highlighting its potential as an antiviral therapy.

Cite This Study

Chen et al. (2004) studied this question.

synapsesocial.com/papers/6a92689c467fa0393241e366 https://doi.org/10.1128/jvi.78.13.6900-6907.2004

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RNA Interference Targeting VP1 Inhibits Foot-and-Mouth Disease Virus Replication in BHK-21 Cells and Suckling Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

RNA Interference Targeting VP1 Inhibits Foot-and-Mouth Disease Virus Replication in BHK-21 Cells and Suckling Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider