Why the study?
Does intravenous ketamine pretreatment reduce propofol injection pain in women presenting for gynaecological surgery?
Does intravenous ketamine pretreatment reduce propofol injection pain in women presenting for gynaecological surgery?
Intravenous ketamine pretreatment significantly reduces the incidence of propofol injection pain in women undergoing gynaecological surgery.
Supports ketamine pretreatment to reduce propofol pain in gynaecological procedures; extends RCT evidence to this population.
A controlled, randomised double-blind study was performed to compare the prior intravenous administration of ketamine 10 mg (1 ml) or 0.9% saline (1 ml) on propofol injection pain. One hundred patients of ASA status 1 or 2 presenting for gynaecological surgery were studied. Following an initial 5-ml bolus of propofol into a dorsal hand vein, 30 s after the treatment, 84% of the saline control patients experienced mild or severe pain compared to 26% of those who were given ketamine pretreatment (p < 0.05).
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Tan et al. (1998) studied this question.
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