Key result
Venous occlusion for 40 or 60 seconds with ketamine pre-treatment significantly reduced the incidence of propofol injection pain to 15% compared to 75% with 20 seconds of occlusion (p<0.001).
Why the study?
Propofol causes uncomfortable pain during administration, prompting evaluation of different venous occlusion durations with ketamine pretreatment to prevent it.
Does venous occlusion for 40 or 60 seconds compared to 20 seconds during ketamine pre-treatment reduce propofol injection pain in patients undergoing general anaesthesia?
Observational (n=60)
No
Does venous occlusion for 40 or 60 seconds compared to 20 seconds during ketamine pre-treatment reduce propofol injection pain in patients undergoing general anaesthesia?
Absolute Event Rate: 15% vs 75%
p-value: p=<0.001
Venous occlusion for 40 seconds during ketamine pre-treatment is as effective as 60 seconds in reducing propofol injection pain, offering a more comfortable alternative to longer tourniquet times.
Supports optimizing occlusion duration with ketamine pretreatment; leaves open confirmation in randomized trials before practice change.
Propofol is rapidly acting intravenous agent used for induction in general anaesthesia.It causes pain while administering,being uncomfortable to patients .So an observational study was done to compare the effects of different time duration of venous occlusion on pretreatment with injection Ketamine for prevention of pain at injection site. After approval of ethical committee and written informed consent,ASA grade I and II,60 patients of either gender, aged between 18-60 years were assigned to three groups of 20 each under GA and divided as GROUP K20,K40,and K60 according to venous occlusion duration of 20,40,and 60 seconds respectively on administration of ketamine(0.2mg/kg)as pretreatment for propofol injection pain.Following injection of ketamine ,25% dose of propofol was given and patient was asked for any sensation of pain at the site of injection and graded accordingly. Haemodynamics were compared in all the three groups. All 60 patients were reviewed for propofol pain and haemodynamics were recorded before pretreatment with ketamine and after pretreatment for 5 minutes and results evaluated through chi square test.P value was significant for 20 seconds (p value <0.001)but not for 40 and 60 seconds(p value 0.201)resulting in no difference in pain score between the two groups as compared to K20 group.
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Mehta et al. (2022) conducted an observational in Propofol injection pain (n=60). Venous occlusion for 40 or 60 seconds with ketamine pre-treatment vs. Venous occlusion for 20 seconds with ketamine pre-treatment was evaluated on Incidence of pain on propofol injection (p=<0.001). Venous occlusion for 40 or 60 seconds with ketamine pre-treatment significantly reduced the incidence of propofol injection pain to 15% compared to 75% with 20 seconds of occlusion (p<0.001).
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