Rapid synthesis of 14C forskolin by a route suitable for 11C labeling

This is the authors' abstract. We don't add key points for this paper.

Radiolabeled forskolin was synthesized by acetylation of deacetylforskolin with 14C‐labeled acetic acid in the presence of dicyclohexylcarbodiimide. Separation of labeled forskolin of greater than 97% radiochemical purity was achieved by HPLC with a reversed‐phase column. The synthesis and purification of labeled forskolin were achieved in less than 30 min and the radiochemical yield of labeled forskolin after HPLC purification was about 30%, These methods are therefore applicable for production of 11C‐forskolin which may be useful for PET second messenger imaging.