February 1, 2001The Journal of PhysiologyOpen Access

Responses of single‐unit carotid body chemoreceptors in adult rats

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Population

Male, adult Sprague-Dawley rats

Design

Preclinical

Authors

Discussion

Rat carotid body data leave human translation open; confirms similar PaO2/PaCO2 sensitivity across species.

Population

Male, adult Sprague-Dawley rats

Intervention

Isocapnic changes in oxygenation (PaO2 34-114 mmHg) and iso-oxic changes in CO2

Outcome

Single-unit carotid chemoreceptor discharge frequency (spikes s-1)surrogate

Carotid body chemoreceptors in adult rats exhibit responses to changes in PaO2 and PaCO2 similar to those observed in other species.

Vidruk et al. (2001) studied this question.

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