October 1, 1998Journal of VirologyOpen Access

Recombinant Measles Viruses with Mutations in the C, V, or F Gene Have Altered Growth Phenotypes In Vivo

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Population

Human thymus/liver (thy/liv) implants engrafted into SCID mice

Comparison

Recombinant measles virus strains bearing… vs Parent sequence-tagged Edmonston strain (EdTag)

Design

Preclinical

Authors

AVAlexandra ValsamakisRoche (United States)HSHenriette SchneiderRuhr University Bochum PAPaul G. AuwaerterJohns Hopkins University

Discussion

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Implication

Animal data implicate measles V protein in replication control and thymocyte effects; extends pathogenesis insights but leaves open human relevance.

Structured PICO

Population

Human thymus/liver (thy/liv) implants engrafted into SCID mice

Intervention

Recombinant measles virus strains bearing mutations in the C protein, V protein, and the 5' untranslated region of the F gene (F 5'UTR)

Comparator

Parent sequence-tagged Edmonston strain (EdTag)

Outcome

Virus replication kinetics, peak titers, and thymocyte survivalsurrogate

The C, V, and F 5'UTR genes are accessory factors required for efficient measles virus replication in vivo, and the V protein plays multiple roles in the pathogenesis of thymus infection.

Cite This Study

Valsamakis et al. (1998) studied this question.

synapsesocial.com/papers/6a92737b6724a03bc54f2f2e https://doi.org/10.1128/jvi.72.10.7754-7761.1998

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Implication

Animal data implicate measles V protein in replication control and thymocyte effects; extends pathogenesis insights but leaves open human relevance.

Recombinant Measles Viruses with Mutations in the C, V, or F Gene Have Altered Growth Phenotypes In Vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Recombinant Measles Viruses with Mutations in the C, V, or F Gene Have Altered Growth Phenotypes In Vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider