Key result
Expression of measles virus V protein balances the accumulation of viral gene products in cell culture and contributes to viral pathogenicity in vivo in cotton rats.
Population
Human U-87 glioblastoma cells and cotton rats infected with recombinant measles viruses
Comparison
Recombinant measles viruses genetically… vs Parental measles virus molecular clone (ED-tag)
Design
Preclinical
Follow-up
48 hours (for cell culture)
Authors
Loading...
Does not support changes in measles management; leaves open V protein targeting for human therapies.
The measles virus V protein acts to balance the accumulation of viral gene products and contributes to viral pathogenicity in vivo.
Tober et al. (1998) studied Measles virus infection. Measles virus V protein expression vs. Parental MV molecular clone (ED-tag) was evaluated on Viral RNA synthesis and infectious virus titers. Expression of measles virus V protein balances the accumulation of viral gene products in cell culture and contributes to viral pathogenicity in vivo in cotton rats.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: