Key result
Ribosomal frameshifting on the measles virus P protein mRNA generates a unique R protein with an estimated frameshift frequency of approximately 1.8%.
Population
Escherichia coli system and eukaryotic cells expressing measles virus P cistron-related mRNAs and proteins
Design
Preclinical
Authors
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Hypothesis-generating for measles virus proteome expansion; requires validation in human cells and pathogenesis models.
This study identifies a novel ribosomal frameshifting mechanism in measles virus that generates a unique R protein, expanding the known coding capacity of the virus.
Liston et al. (1995) studied Measles virus infection. Ribosomal frameshifting on measles virus P protein mRNA was evaluated on Frameshift frequency and detection of R protein. Ribosomal frameshifting on the measles virus P protein mRNA generates a unique R protein with an estimated frameshift frequency of approximately 1.8%.
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