November 1, 1988Journal of VirologyOpen Access

Expression of bicistronic measles virus P/C mRNA by using hybrid adenoviruses: levels of C protein synthesized in vivo are unaffected by the presence or absence of the upstream P initiator codon

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Population

293 cells (which provide complementary E1a-E1b functions)

Comparison

Infection with hybrid human adenoviruses… vs Measles virus (MV) infection

Design

Preclinical

Authors

GAGhalib AlkhatibCalifornia Northstate University BMB. MassieBiotechnology Research Institute DBDalius J. BriedisMcGill University

Discussion

Member takes

Implication

Supports internal ribosome entry for measles C protein; hypothesis-generating for paramyxovirus translation requiring in vivo confirmation.

Structured PICO

Population

293 cells (which provide complementary E1a-E1b functions)

Intervention

Infection with hybrid human adenoviruses Ad5MV/PC13 (containing both 5'-proximal AUG codons of the P/C mRNA) or Ad5MV/C3 (retaining only the second AUG codon)

Comparator

Measles virus (MV) infection

Outcome

Levels of C protein synthesized and P/C-specific mRNA transcription

The level of measles virus C protein expression is unaffected by the presence or absence of an upstream P initiator codon, suggesting ribosomes may bind directly at an internal mRNA site.

Cite This Study

Alkhatib et al. (1988) studied this question.

synapsesocial.com/papers/6a8a6c641fb56efa37d49c2d https://doi.org/10.1128/jvi.62.11.4059-4069.1988

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Implication

Supports internal ribosome entry for measles C protein; hypothesis-generating for paramyxovirus translation requiring in vivo confirmation.

Expression of bicistronic measles virus P/C mRNA by using hybrid adenoviruses: levels of C protein synthesized in vivo are unaffected by the presence or absence of the upstream P initiator codon

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Expression of bicistronic measles virus P/C mRNA by using hybrid adenoviruses: levels of C protein synthesized in vivo are unaffected by the presence or absence of the upstream P initiator codon

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider