What question did this study set out to answer?

To characterize atheroprotective antibodies targeting phosphorylcholine and oxidized lipoproteins in patients with ANCA-associated vasculitis.

May 2, 2015European Journal of Clinical Investigation

Phosphorylcholine antibodies are diminished in ANCA ‐associated vasculitis

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Authors

BWBenjamin WildeUniversity of Antwerp MSMarjan C. SlotMaastricht University Medical Centre PPPieter van PaassenMaastricht University Medical Centre

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Implication

Case-control study reveals diminished atheroprotective phosphorylcholine and oxidized LDL antibodies in ANCA-associated vasculitis, indicating a mechanism for accelerated atherosclerosis.

Key Points

To characterize atheroprotective antibodies targeting phosphorylcholine and oxidized lipoproteins in patients with ANCA-associated vasculitis.
Measured serum anti-phosphorylcholine (anti-Pc) and anti-oxidized low-density lipoprotein (anti-OxLDL) antibodies in 39 patients with ANCA-associated vasculitis and 44 healthy controls.
Assessed carotid intima-media thickness (IMT) and femoral pulse wave velocity (PWV) to evaluate vascular structure and arterial stiffness.
Anti-Pc and anti-OxLDL IgM antibody levels were significantly reduced in patients with ANCA-associated vasculitis compared with healthy controls.
Carotid IMT and femoral PWV were negatively associated with anti-Pc antibodies in healthy controls only, with no significant correlation observed in vasculitis patients.

Cite This Study

Wilde et al. (2015) studied this question.

synapsesocial.com/papers/6a927ab17f7f92597e181ea9 https://doi.org/10.1111/eci.12457

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Implication

Case-control study reveals diminished atheroprotective phosphorylcholine and oxidized LDL antibodies in ANCA-associated vasculitis, indicating a mechanism for accelerated atherosclerosis.

Phosphorylcholine antibodies are diminished in ANCA ‐associated vasculitis

Discussion

Member takes

Implication

Key Points

Cite This Study

Phosphorylcholine antibodies are diminished in ANCA ‐associated vasculitis

Discussion

Member takes

Implication

Key Points

Cite This Study

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