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From these experiments it is apparent that trans isomers of the “essential” fatty acids are converted to inactive forms of polyunsaturated acids which are, however, detectable spectrophotometrically. Conversely, the detection of polyunsaturated acid in a tissue does not imply that these substances are biologically active. However, this factor is not likely to affect studies of animals fed natural diets.
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R. T. Holman (1951) studied this question.
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