Electrophoretic Studies of the Plasma and Serum Proteins in Sickle Cell Anemia 1

Richard L. Fenichel; Janet Watson; F. R. Eirich

doi:10.1172/jci102405

December 1, 1950Journal of Clinical InvestigationOpen Access

Electrophoretic Studies of the Plasma and Serum Proteins in Sickle Cell Anemia 1

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Key Points

Determine the distribution and concentration of electrophoretic protein fractions in the plasma and serum of individuals with sickle cell anemia.
Conducted electrophoretic analysis on plasma and serum protein samples from patients with sickle cell anemia.
Measured total protein concentrations and quantified relative percentages and absolute amounts of distinct protein fractions, including albumin and globulins.
Albumin relative percentages ranged from 39.4% to 50.4% across tested individuals, corresponding to absolute concentrations between 3.15 and 3.58 g/dL.
Total serum protein values ranged from 6.2 to 7.8 g/dL, with gamma globulin levels reaching up to 36.3% (2.96 g/dL) and albumin-to-globulin ratios between 0.7 and 1.0.

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Implication

Observational study reveals altered plasma and serum protein fraction distributions in sickle cell anemia, highlighting shifts in circulating protein profiles.

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Fenichel et al. (1950) studied this question.

synapsesocial.com/papers/6a927ede2513ed2118181f5d https://doi.org/10.1172/jci102405

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Electrophoretic Studies of the Plasma and Serum Proteins in Sickle Cell Anemia 1

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Discussion

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Electrophoretic Studies of the Plasma and Serum Proteins in Sickle Cell Anemia 1

Key Points

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