Why the study?
Does isoflurane lower pulmonary arterial pressure and pulmonary vascular resistance in a patient with primary pulmonary hypertension during surgery?
Does isoflurane lower pulmonary arterial pressure and pulmonary vascular resistance in a patient with primary pulmonary hypertension during surgery?
Isoflurane may be a safe and beneficial anesthetic agent for lowering pulmonary arterial pressure and vascular resistance in patients with primary pulmonary hypertension undergoing short surgical procedures.
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May support isoflurane in primary pulmonary hypertension anesthesia; hypothesis-generating case report requiring prospective validation.
Primary pulmonary hypertension is a rare and fatal disease. These patients represent an anaesthetic challenge because of the high mortality associated with the marked intra-operative increase in pulmonary vascular resistance and right ventricular decompensation. This is a first case report which demonstrates the safe and beneficial effects of isoflurane in lowering pulmonary arterial pressure and pulmonary vascular resistance in such a patient for a short surgical procedure. The anaesthetic considerations in these patients are discussed.
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Cheng et al. (1988) studied this question.
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