Why the study?
Does Met-RANTES reduce cardiac inflammation and improve survival in mice with acute Trypanosoma cruzi-elicited myocarditis?
Population
C3H/HeJ mice infected with 100 blood trypomastigotes of Trypanosoma cruzi
Comparison
Met-RANTES (a selective CCR1 and CCR5 antagonist) vs Saline treatment
Design
Preclinical
Follow-up
acute/early phase of infection
Authors
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May support CCR1/CCR5 blockade in experimental Chagas myocarditis; leaves open translation to human trials.
Does Met-RANTES reduce cardiac inflammation and improve survival in mice with acute Trypanosoma cruzi-elicited myocarditis?
In a mouse model of T cruzi-elicited myocarditis, antagonism of CCR1 and CCR5 with Met-RANTES reduced cardiac inflammation and improved survival without affecting parasitism.
Marino et al. (2004) studied this question.
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