Historical context noting that 50% nitrous-oxide/air analgesia in labor is often inadequate and carries a risk of hypoxia.
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50% nitrous oxide may be inadequate for labor analgesia with hypoxia risk; leaves open optimal modern dosing and alternatives.
In 1934 Minnitt 1 introduced an apparatus for the self-administration of nitrous-oxide/air analgesia in labour under the general supervision of the midwife. In 1949 Seward showed that the two main disadvantages of 'gas and air' were firstly, that the 50 % nitrous-oxide given by the apparatus was frequently too weak to provide adequate analgesia and secondly, that after breathing the mixture for a short time, the mother and the baby were likely to become hypoxic, a point recently confirmed by Cole and Nainby-Luxmoorez.
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McANENY et al. (1963) studied this question.
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