Vaccines and vaccination are at a turning point.Recent advances in microbial genetics and in immunology have greatly increased our understanding of microbial pathogenesis and of host defence mechanisms.As a result, within the next 10-15 years, a whole set of new preventive vaccines should become available.These will not only be used to prevent infectious diseases but also for preventing neoplasms such as stomach and endocervical cancer.Also under development are therapeutic vaccines to treat autoimmune diseases and allergic disorders.This review outlines some of the advances in biology, development of new vaccines, and vaccination strategies and discusses the factors that will determine the extent of their use in the future.
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Lambert et al. (1997) studied this question.
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