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Blood plasma lipid fractions and their component fatty acids were determined on six normal cows: two each of the Guernsey, Holstein, and Jersey breeds; and on two cows with clinical ketosis, one each of the Guernsey and Jersey breeds. Breed differences, either in lipid fractions or component fatty acids, were minor. The total plasma lipids were reduced to approximately two-thirds of normal in the ketotic cows. All lipid fractions, except free fatty acids which were elevated tenfold, declined. Ketotic cows exhibited compositional changes in all lipid fractions. Palmitic acid was elevated in all lipid fractions except free fatty acids. Stearic acid decreased and oleic acid was increased. Linoleic acid, appearing primarily in the phospholipids and cholesterol esters, decreased in these fractions in the ketotic cow. These compositional changes and lowered total lipids suggest metabolic changes in the liver of ketotie cows.
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Yamdagni et al. (1970) studied this question.
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