Engineering study demonstrates high-voltage bipolar neurostimulation using low-voltage CMOS transistors, indicating safe and compact integration for neural prosthetics.
This paper presents the design of a bipolar current-mode stimulator integrated circuit (IC) for implantable prosthetic devices using 0.18-μm standard CMOS process. The proposed stimulator IC is capable of delivering up to 1-mA current through 10-kΩ load using 12.8 V supply voltage. The output impedance of the stimulator is enhanced by utilizing a regulated cascode output current driver stage, which achieves a voltage compliance of 12.4 V. In order to allow low-voltage standard transistors to operate reliably at high voltage, transistor stacking and dynamic gate biasing techniques are used. In addition, a simple active charge balancing circuit is included to achieve minimal net charge after stimulation cycle is complete. The overall layout area is 0.12 mm².
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Vo et al. (2026) studied this question.
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