What does this research mean for the field?

A one-week course of topical bromfenac combined with topical corticosteroid therapy significantly reduces postoperative increases in macular thickness and the incidence of pseudophakic cystoid macular edema compared to corticosteroid monotherapy after cataract surgery. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To compare the efficacy of a one-week postoperative regimen of topical bromfenac combined with corticosteroid versus corticosteroid monotherapy in preventing pseudophakic cystoid macular edema (PCME).

August 29, 2026PLoS ONEOpen Access

Efficacy of a one-week course of topical bromfenac combined with corticosteroid for prevention of pseudophakic cystoid macular edema (PCME)

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Authors

YKYoon Soo KimKorea University MSMyung-Sun SongKorea University YEYoungsub EomEmory University

Discussion

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Implication

Retrospective study shows reduced macular edema risk with bromfenac and corticosteroid combination after cataract surgery, indicating improved postoperative retinal protection.

Key Points

To compare the efficacy of a one-week postoperative regimen of topical bromfenac combined with corticosteroid versus corticosteroid monotherapy in preventing pseudophakic cystoid macular edema (PCME).
Retrospective comparative study evaluating 226 eyes of 226 patients undergoing uneventful phacoemulsification.
Group A (n = 158) received topical bromfenac 0.1% twice daily plus prednisolone acetate 1% (PDE) 6 times daily or every 2 hours while awake; Group B (n = 68) received PDE monotherapy for the first postoperative week.
Spectral-domain optical coherence tomography was performed preoperatively and at postoperative week 5 to evaluate central subfield macular thickness (CSMT) changes and the incidence of PCME.
Postoperative absolute and relative CSMT increases were significantly smaller in Group A (13.3 ± 13.0 μm, 5.6 ± 5.3%) than in Group B (27.0 ± 33.7 μm, 11.2 ± 14.3%; p = 0.002).
The incidence of optical coherence tomography-defined PCME was significantly lower in Group A than in Group B (5.1% vs. 16.2%; OR = 0.28; 95% CI, 0.11–0.72; p = 0.006).
Among eyes with PCME, median CSMT elevation was lower in Group A than in Group B (38.5 μm vs. 80.0 μm; p = 0.031), with a trend toward lower PCME rates with hourly-dosed PDE within the combination group (2.0% vs. 10.0%; OR = 0.19; 95% CI, 0.04–0.79; p = 0.054).

Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/6a9299958e5d7d1fc0c119c2 https://doi.org/10.1371/journal.pone.0356992

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Implication

Retrospective study shows reduced macular edema risk with bromfenac and corticosteroid combination after cataract surgery, indicating improved postoperative retinal protection.

Efficacy of a one-week course of topical bromfenac combined with corticosteroid for prevention of pseudophakic cystoid macular edema (PCME)

Discussion

Member takes

Implication

Key Points

Cite This Study

Efficacy of a one-week course of topical bromfenac combined with corticosteroid for prevention of pseudophakic cystoid macular edema (PCME)

Discussion

Member takes

Implication

Key Points

Cite This Study

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