Experimental study reveals sex-specific NDUFS4 phosphorylation drives adolescent cannabis effects, highlighting mitochondrial pathways as viable therapeutic targets.
Adolescent cannabis use produces lasting and sex-specific effects into adulthood, although poorly explained mechanistically. This study links these cannabis-induced effects to sex-dependent changes in phosphorylation of mitochondrial Complex I subunit NDUFS4 during adolescence, identifying mitochondrial pathways as causal mechanisms and potential therapeutic targets to reduce their long-term consequences.
No takes yet. Share an insight, caveat, or question.
Ioannidou et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: