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August 29, 2026International Wound JournalOpen Access

Angiosarcoma Presenting as a Chronic Non‐Healing Lower Extremity Ulcer in Lymphoedema: A Challenge

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Authors

MKMegan KochLHLeena HaniEFErica B. Friedman

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Overview

Case report demonstrates angiosarcoma masquerading as a chronic lower extremity ulcer in chronic lymphoedema, highlighting the critical role of early biopsy for persistent wounds.

Key Points

  • To describe an atypical clinical presentation of cutaneous angiosarcoma mimicking a chronic lower extremity ulcer in a patient with chronic lymphoedema and emphasize the importance of prompt diagnostic biopsy.
  • Evaluated the clinical presentation, diagnostic evaluation, histopathological findings, and management course of a 74-year-old female presenting with a persistent, non-healing lower extremity ulcer.
  • Histopathologic analysis via biopsy confirmed cutaneous angiosarcoma following conservative treatment failure for presumed cellulitis and venous ulceration.
  • Treatment with complete surgical resection and adjuvant radiotherapy resulted in disease-free survival exceeding 4 years prior to recurrence and patient death.

Cite This Study

Koch et al. (2026) studied this question.

synapsesocial.com/papers/6a9299ac8e5d7d1fc0c11c28https://doi.org/10.1111/iwj.71002
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