What does this research mean for the field?

In patients with esophageal squamous cell carcinoma treated with neoadjuvant chemoradiotherapy and esophagectomy, poor pathological response is associated with earlier, predominantly locoregional recurrence, while favorable response is associated with a higher proportion of systemic recurrence. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate how tumor regression grade relates to the patterns, timing, and survival outcomes of cancer recurrence after neoadjuvant chemoradiotherapy and esophagectomy in esophageal squamous cell carcinoma.

August 29, 2026Korean Journal of Clinical OncologyOpen Access

Pathological tumor response and its association with recurrence patterns and survival after neoadjuvant chemoradiotherapy and esophagectomy for esophageal squamous cell carcinoma: a tertiary care center experience from India

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To evaluate how tumor regression grade relates to the patterns, timing, and survival outcomes of cancer recurrence after neoadjuvant chemoradiotherapy and esophagectomy in esophageal squamous cell carcinoma.
Retrospectively analyzed 129 patients with esophageal squamous cell carcinoma who underwent neoadjuvant chemoradiotherapy followed by radical esophagectomy between January 2013 and June 2023 in India.
Categorized pathological tumor response using the College of American Pathologists tumor regression grade (TRG) system into TRG 0 (complete), TRG 1 (near-complete), TRG 2 (partial), and TRG 3 (poor/no response).
Overall recurrence occurred in 25.6% of patients (33/129), with systemic recurrence being the most frequent (48.5%, 16/33), followed by combined locoregional and systemic (27.3%, 9/33) and isolated locoregional recurrence (24.2%, 8/33).
Patients with TRG 0 had the lowest rate of isolated locoregional recurrence (16.7%), whereas TRG 3 patients predominantly experienced isolated locoregional recurrence (80.0%), with all recurrences in the TRG 3 cohort occurring within 12 months.

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Implication

Retrospective study reveals distinct recurrence patterns linked to tumor response in esophageal squamous cell carcinoma, indicating the need for risk-tailored postoperative surveillance.

Cite This Study

Khan et al. (2026) studied this question.

synapsesocial.com/papers/6a9299bb8e5d7d1fc0c11dbb https://doi.org/10.14216/kjco.26387

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Implication

Retrospective study reveals distinct recurrence patterns linked to tumor response in esophageal squamous cell carcinoma, indicating the need for risk-tailored postoperative surveillance.

Pathological tumor response and its association with recurrence patterns and survival after neoadjuvant chemoradiotherapy and esophagectomy for esophageal squamous cell carcinoma: a tertiary care center experience from India

Key Points

Discussion

Implication

Cite This Study

Pathological tumor response and its association with recurrence patterns and survival after neoadjuvant chemoradiotherapy and esophagectomy for esophageal squamous cell carcinoma: a tertiary care center experience from India

Key Points

Discussion

Implication

Cite This Study

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