Why the study?
Does the dextromethorphan metabolic ratio correlate with propafenone metabolism in Chinese patients with paroxysmal atrial fibrillation?
Population
60 Chinese patients with paroxysmal atrial fibrillation from Hong Kong
Design
Cohort
Authors
Loading...
May inform propafenone dosing via dextromethorphan phenotyping in Chinese AF patients; leaves open prospective validation for clinical adoption.
Does the dextromethorphan metabolic ratio correlate with propafenone metabolism in Chinese patients with paroxysmal atrial fibrillation?
A significant proportion (15%) of Chinese patients with atrial fibrillation in Hong Kong are poor CYP2D6 metabolizers, and their ability to metabolize dextromethorphan correlates with propafenone metabolism.
Chow et al. (2001) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: