Why the study?
What is the frequency of the CYP2C19*17 allele in a Japanese population and its impact on metabolic activity?
What is the frequency of the CYP2C19*17 allele in a Japanese population and its impact on metabolic activity?
The CYP2C19*17 allele, associated with increased metabolic activity, has a very low frequency (1.3%) in the Japanese population, suggesting it plays a minor role in interindividual variability of CYP2C19 activity in this group.
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Low CYP2C19*17 prevalence suggests negligible clinical impact in Japanese patients; leaves open identification of other drivers of variability.
Sugimoto et al. (2008) studied this question.
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