Key result
Carotid stenting reduced blood flow to the external carotid artery and enhanced local flow disturbance, with increased stent length worsening disturbed flow near the strut.
Why the study?
Carotid stenting near the bifurcation carina is clinically associated with adverse events such as in-stent restenosis, thrombosis, and side branch occlusion, but the biomechanical mechanisms remain unclear.
Computational modeling reveals that carotid stenting alters local hemodynamics, particularly increasing abnormal flow in the external carotid artery, which may explain adverse events like restenosis and thrombosis.
Answers are grounded in this paper and cite their sources.
Should not yet change carotid stenting practice; hypothesis-generating for stent design effects on hemodynamics.
Carotid stenting near the bifurcation carina is associated with adverse events, especially in-stent restenosis, thrombosis, and side branch occlusion in clinical data. This study is aimed at determining the potential biomechanical mechanisms for these adverse events after carotid stenting. The patient-specific carotid models were constructed with different stenting scenarios to study the flow distribution and hemodynamic parameters, such as wall shear stress (WSS), flow velocity, relative residence time (RRT), and oscillating shear index (OSI) in the carotid bifurcation. The results suggested that the existing stents surely reduced blood flow to the external carotid artery (ECA) but enhanced local flow disturbance both in ECA and stented internal carotid artery (ICA), and the inner posterior wall of the stented ICA and the outer posterior wall of ECA might endure a relatively low level of WSS and remarkably elevated OSI and RRT. In addition, the implanted stent leads to more ECA adverse flow than ICA after stenting. While disturbed flow near the strut increased as stent length increased, blood flow and areas of local flow disturbance in ECA slightly decreased as stent length increased. In conclusion, the results revealed that ECA might be in relatively high levels of abnormal local hemodynamics after stenting, followed by stented ICA, leading to potential adverse events after intervention.
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Liu et al. (2021) studied Carotid stenting near the bifurcation carina. Carotid stenting was evaluated on Flow distribution and hemodynamic parameters (WSS, flow velocity, RRT, and OSI). Carotid stenting reduced blood flow to the external carotid artery and enhanced local flow disturbance, with increased stent length worsening disturbed flow near the strut.
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