Key result
Heparin-induced thrombocytopenia caused spontaneous thrombosis in a previously untreated native coronary artery, resulting in an ST-elevation myocardial infarction in a 67-year-old woman.
Why the study?
Heparin-induced thrombocytopenia thrombotic events rarely affect the coronary arteries, particularly presenting as spontaneous thrombosis in previously untreated native coronary arteries.
Case Report (n=1)
This case demonstrates that spontaneous thrombosis can occur in a previously untreated native coronary artery in a patient with heparin-induced thrombocytopenia.
HIT may underlie unexplained native coronary STEMI; extends known HIT thrombotic spectrum and leaves open screening or prevention strategies.
BACKGROUND: Heparin-induced thrombocytopenia (HIT) is a rare complication of heparin therapy. Its pathogenesis includes thrombotic events that can rarely affect the coronary arteries. CASE SUMMARY: We report a 67-year-old woman who presented with extensive lower extremities deep venous thrombosis. After being treated with heparin, she developed an ST-elevation myocardial infarction secondary to an acute thrombus formation. The patient's platelets dropped within 6 days from the procedure and her heparin-PF4 IgG antibody and serotonin release assay were positive confirming the diagnosis of HIT. DISCUSSION: Prothrombotic states, such as HIT, are associated with increased risk for coronary thrombosis and ischaemia. Heparin-induced thrombocytopenia can cause coronary complications usually in previously disrupted coronary vessels and bypass grafts. Here, we demonstrate that spontaneous thrombosis can occur in a previously untreated native coronary artery in a patient with HIT.
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Almeqdadi et al. (2018) conducted a case report in Heparin-induced thrombocytopenia (HIT) (n=1). Heparin was evaluated on ST-elevation myocardial infarction. Heparin-induced thrombocytopenia caused spontaneous thrombosis in a previously untreated native coronary artery, resulting in an ST-elevation myocardial infarction in a 67-year-old woman.
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