Key result
LMWH exposure linked to severe HIT causing multi-vessel coronary thrombosis and STEMI.
Why the study?
Heparin-induced thrombocytopenia is a rare condition with severe complications and is uncommon with low molecular weight heparin, especially causing multi-vessel coronary artery thrombosis.
Case Report (n=1)
No
Answers are grounded in this paper and cite their sources.
HIT secondary to low molecular weight heparin can rarely present as multi-vessel coronary thrombosis and STEMI, and should be considered in patients with recent exposure.
Heparin is an anticoagulant which has been widely used in various clinical settings, from thromboprophylaxis to the treatment of thromboembolism. Heparin-induced thrombocytopenia (HIT) is a rare medical condition with severe complications if unrecognised, and it carries significant risks of co-morbidities and mortality. The incidence of HIT is relatively less common in low molecular weight heparin. HIT is more common in the venous system than the arterial circulatory system, and it is rare to see multi-vessel coronary artery thrombosis due to HIT. We hereby report a case of multi-vessel coronary thrombosis secondary to low molecular weight HIT, presenting as a case of ST-segment elevation myocardial infarction. We learned from the case that low molecular weight heparin can cause thrombosis secondary to HIT and HIT could be one of the differential diagnoses in those presenting with ST-elevation myocardial infarct and recent exposure to low molecular weight heparin.
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Hein et al. (2023) conducted a case report in Heparin-Induced Thrombocytopenia with Native Coronary Artery Thrombosis (n=1). Low molecular weight heparin (Dalteparin) was evaluated on Development of multi-vessel coronary artery thrombosis and HIT. Exposure to low molecular weight heparin can cause severe heparin-induced thrombocytopenia resulting in multi-vessel native coronary artery thrombosis and ST-elevation myocardial infarction.
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