Key result
Decreased serum antithrombin activity was associated with severe coronary artery disease, with 90% of patients with low activity having two or three vessels occluded.
Why the study?
Does serum antithrombin activity correlate with coronary angiographic findings in patients with documented angina?
Cross-Sectional (n=69)
Does serum antithrombin activity correlate with coronary angiographic findings in patients with documented angina?
Absolute Event Rate: 90% vs 10%
Decreased serum antithrombin activity is strongly correlated with multi-vessel coronary artery disease in patients with angina, potentially identifying candidates for clot-preventive therapies.
May warrant prospective validation in angina; cross-sectional data leave open clinical utility of antithrombin testing.
Serum antithrombin activity (AA) was correlated with coronary angiographic findings in 69 patients with documented angina. There was excellent correlation between normal values and normal coronary circulation or only one-vessel stenosis in 30 of 35 patients (86%). When AA was above 90%, 90% of patients (20 of 22) had normal circulation or one-vessel occlusion. In 24 patients AA values were significantly decreased. Coronary angiography in this group revealed three with normal circulation or only one-vessel involvement (10%); 21 of 24 had two or three vessels occluded (90%). The correlation between severe CAD and low AA is probably coincidental to a "triggered" or "turned-on" clotting system. The most practical clinical contribution of AA estimation relates to this capacity to identify angina patients in whom clot-preventive measures (aspirin; dipyridamole; anticoagulants) might prove beneficial.
No takes yet. Share an insight, caveat, or question.
Innerfield et al. (1976) conducted a cross-sectional in Coronary-artery Disease (n=69). Decreased serum antithrombin activity vs. Normal serum antithrombin activity was evaluated on Two or three vessels occluded on coronary angiography. Decreased serum antithrombin activity was associated with severe coronary artery disease, with 90% of patients with low activity having two or three vessels occluded.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: