Key result
Intrarenal infusion of angiotensin II in rats reduced the glomerular ultrafiltration coefficient (0.84 vs 1.43 microliters/s/mmHg) without altering epithelial cell or filtration slit structure.
Authors
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Ang II may impair glomerular filtration via functional rather than structural changes in rats; leaves open relevance to human disease.
Absolute Event Rate: 0.84% vs 1.43%
Pagtalunan et al. (1995) studied Glomerular function and structure. Angiotensin II vs. Control animals was evaluated on Glomerular ultrafiltration coefficient (Kf). Intrarenal infusion of angiotensin II in rats reduced the glomerular ultrafiltration coefficient (0.84 vs 1.43 microliters/s/mmHg) without altering epithelial cell or filtration slit structure.
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